Semax
30mg
A synthetic peptide based on an ACTH fragment, used in neurotrophic signaling studies.
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Research details
Areas of research interest
Semax is studied for stroke recovery, cognitive function, and neuroprotection. In Russia it is on the national list of essential drugs and is used for stroke, transient ischemic attack, and cognitive disorders. Semax is not approved by FDA or any Western regulator.
Overview
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide based on a fragment of adrenocorticotropic hormone, ACTH(4-10). It keeps the ACTH(4-7) sequence and adds a stabilizing Pro-Gly-Pro tail, and it does not act as a hormone on the adrenal glands. Its exact mechanism of action is not established.
Research summary
Neurotrophic effects. In rats, Semax regulated expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus [1].
Stroke. A Russian study of 110 patients recovering from ischemic stroke reported higher BDNF levels with Semax, which correlated with early rehabilitation progress.
Evidence base. Most Semax research comes from Russian groups, and large Western randomized trials have not been conducted.
References
- 1. Dolotov OV, et al. Brain Res. 2006;1117(1):54–60. PMID: 16996037
For laboratory research use only. Not for human or veterinary use. This product is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.