NAD+
500mg / 1000mg
Nicotinamide adenine dinucleotide, a central coenzyme used in cellular metabolism research.
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Research details
Areas of research interest
NAD+ is studied in aging, energy metabolism, and neurodegenerative disease research, because cellular NAD+ levels decline with age. Research on raising NAD+ includes both precursor molecules and direct administration of NAD+ itself. NAD+ in this form is not approved by FDA for any use.
Overview
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme, not a peptide. It is required for roughly 500 enzymatic reactions and is one of the most abundant molecules in the human body [1]. It carries electrons in redox reactions and regulates NAD+-sensing enzymes involved in energy metabolism and cell survival [1].
Research summary
Aging. NAD+ levels decline steadily with age, which is associated with altered metabolism and greater disease susceptibility [1]. Restoring NAD+ in old or diseased animals has improved health measures and extended lifespan [1].
Direct administration. A pilot study in healthy men tracked NAD+ and its breakdown products during a 6-hour intravenous infusion [2]. NAD+ was rapidly and completely removed from plasma for at least the first 2 hours, and the metabolites pointed to enzymatic breakdown [2].
References
- 1. Rajman L, Chwalek K, Sinclair DA. Cell Metab. 2018;27(3):529–547. PMID: 29514064
- 2. Grant R, et al. Front Aging Neurosci. 2019;11:257. PMID: 31572171
For laboratory research use only. Not for human or veterinary use. This product is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.