MOTS-C
10mg / 30mg
A mitochondrial-derived peptide studied in cellular energy and metabolic stress models.
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Research details
Areas of research interest
MOTS-c is studied for insulin sensitivity, obesity, and age-related physical decline. Because its effects in mice resemble some effects of exercise, it is often described as an exercise-mimetic research peptide. MOTS-c is not approved by FDA for any use, and no human efficacy trials have been completed.
Overview
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA, within the 12S rRNA gene, rather than in the cell nucleus. It belongs to a small family of mitochondrial-derived peptides. Its main target tissue is skeletal muscle, where it inhibits the folate cycle and activates AMPK, a central regulator of cellular energy.
Research summary
Metabolism. In mice, MOTS-c treatment prevented both age-related and high-fat-diet-induced insulin resistance, as well as diet-induced obesity [1].
Exercise and aging. MOTS-c levels rise with exercise, and treating aged mice improved physical performance and muscle function [2].
References
- 1. Lee C, et al. Cell Metab. 2015;21(3):443–454. PMID: 25738459
- 2. Reynolds JC, et al. Nat Commun. 2021;12(1):470. PMID: 33473109
For laboratory research use only. Not for human or veterinary use. This product is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.