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GLP-1 T
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A tirzepatide-class dual-receptor research compound used in preclinical metabolic signaling studies.

GLP-1 T 10mg research compound vial

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Research details

Areas of research interest

Tirzepatide is studied mainly for glycemic control in type 2 diabetes and for body-weight reduction. Because it acts on both GIP and GLP-1 receptors, it serves as a common reference compound in incretin research. Tirzepatide is the active ingredient in FDA-approved prescription medicines. This research-grade material is not one of those products and is not for human use.

Overview

Tirzepatide is a synthetic 39-amino-acid peptide that acts as a dual agonist at the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. A C20 fatty diacid side chain promotes albumin binding and extends its circulating half-life.

Research summary

Type 2 diabetes. In the SURPASS-2 trial of 1,879 adults with type 2 diabetes, all three tirzepatide arms were noninferior and superior to semaglutide for HbA1c reduction at 40 weeks, with greater body-weight reduction [1]. Gastrointestinal events were the most common adverse effects in both groups [1].

Obesity. In SURMOUNT-1, 2,539 adults with obesity or overweight but without diabetes lost a mean 15.0% to 20.9% of body weight at 72 weeks across the three tirzepatide arms, compared with 3.1% on placebo [2]. Adverse events led to discontinuation in 4.3% to 7.1% of tirzepatide participants [2].

Regulatory status. FDA approved tirzepatide for type 2 diabetes in May 2022. Later approvals covered chronic weight management (November 2023) and obstructive sleep apnea in adults with obesity (December 2024).

References

  1. 1. Frías JP, et al. N Engl J Med. 2021;385(6):503–515. PMID: 34170647
  2. 2. Jastreboff AM, et al. N Engl J Med. 2022;387(3):205–216. PMID: 35658024

For laboratory research use only. Not for human or veterinary use. This product is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.