5-Amino-1MQ
50mg
A small-molecule NNMT inhibitor used in cellular energy-metabolism research.
Bundle & save
Strength
- Ships in 24 hours
- HPLC & endotoxin verified
- Encrypted checkout
Research details
Areas of research interest
5-Amino-1MQ is studied for obesity, fat metabolism, and insulin sensitivity, with newer work on muscle function in aging. It works by blocking an enzyme linked to fat storage and NAD+ metabolism. All published research is in animals and cells; it is not approved by FDA for any use.
Overview
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule, not a peptide. It selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that is upregulated in the fat and liver tissue of obese mice.
Research summary
Obesity models. In diet-induced obese mice, 5-Amino-1MQ significantly reduced body weight, white fat mass, fat cell size, and total cholesterol [1]. Food intake did not change, and no adverse effects were observed [1]. The compound was highly selective and did not inhibit related enzymes in the NAD+ salvage pathway [1].
Metabolic follow-up. A later study in obese mice found dose-dependent limits on weight and fat gain, along with improved glucose tolerance and insulin sensitivity [2].
References
- 1. Neelakantan H, et al. Biochem Pharmacol. 2018;147:141–152. PMID: 29155147
- 2. PMID: 39161060 (2024 study of 5A1MQ in diet-induced obese mice)
For laboratory research use only. Not for human or veterinary use. This product is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.